Drosophila heterochromatin: structure and function

Abstract : Heterochromatic domains, which are enriched in repetitive sequences and packaged in a higher-order chromatin folding, carry the potential to epigenetically inactivate a euchromatic gene that has been moved in close proximity. The discovery that these domains encode non-coding RNAs involved in RNA-silencing mechanisms has recently contributed to a better understanding of the mechanisms of the epigenetic repression established by heterochromatic domains. In this review, we will consider the repeated nature of their DNA sequence, the successive steps in heterochromatin assembly, starting with the decision process, the higher order state assembly and its epigenetic propagation. Recent findings provide new insights into the cellular functions of heterochromatin, notably its major contribution to genome stability and chromosome integrity.
Type de document :
Article dans une revue
Current Opinion in Insect Science, Elsevier, 2014, 1, pp.Pages 19-24. 〈10.1016/j.cois.2014.04.003〉
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Contributeur : Camille Meyer <>
Soumis le : vendredi 25 juillet 2014 - 16:34:50
Dernière modification le : jeudi 7 février 2019 - 16:23:44




Rana Mteirek, Nathalie Guegen, Silke Jensen, Emilie Brasset, Chantal Vaury. Drosophila heterochromatin: structure and function. Current Opinion in Insect Science, Elsevier, 2014, 1, pp.Pages 19-24. 〈10.1016/j.cois.2014.04.003〉. 〈hal-01051087〉



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