Bleomycin-induced double-strand breaks in mitochondrial DNA of Drosophila cells are repaired.

Abstract : Mitochondrial DNA lesions cause numerous human diseases, and it is therefore important to identify the mechanisms whereby the mitochondrion repairs the damage. We have studied in cultured Drosophila cells the repair of bleomycin-induced double-strand breaks (DSBs) in mitochondrial DNA. Our results show that DSBs are repaired as rapidly and effectively in the mitochondria as in the nucleus. DNA repair is complete within 2h following bleomycin treatment, showing that Drosophila mitochondria have an effective system of DSB repair. The mechanism and mitochondrial proteins involved remain to be identified.
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Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Elsevier, 2008, 637 (1-2), pp.111-7. 〈10.1016/j.mrfmmm.2007.07.007〉
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https://hal-clermont-univ.archives-ouvertes.fr/hal-01063346
Contributeur : Camille Meyer <>
Soumis le : jeudi 11 septembre 2014 - 18:29:50
Dernière modification le : vendredi 15 décembre 2017 - 09:18:22

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Frédéric Morel, Monique Renoux, Philippe Lachaume, Serge Alziari. Bleomycin-induced double-strand breaks in mitochondrial DNA of Drosophila cells are repaired.. Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis, Elsevier, 2008, 637 (1-2), pp.111-7. 〈10.1016/j.mrfmmm.2007.07.007〉. 〈hal-01063346〉

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