Trans-generational Immune Priming Protects the Eggs Only against Gram-Positive Bacteria in the Mealworm Beetle - Université Clermont Auvergne Accéder directement au contenu
Article Dans Une Revue PLoS Pathogens Année : 2015

Trans-generational Immune Priming Protects the Eggs Only against Gram-Positive Bacteria in the Mealworm Beetle

Caroline Zanchi
  • Fonction : Auteur
  • PersonId : 767343
  • IdRef : 17234929X
Jérôme Moreau
Maria Teixeira
Yannick Moret
  • Fonction : Auteur
  • PersonId : 842231

Résumé

In many vertebrates and invertebrates, offspring whose mothers have been exposed to pathogens can exhibit increased levels of immune activity and/or increased survival to infection. Such phenomena, called “Trans-generational immune priming” (TGIP) are expected to provide immune protection to the offspring. As the offspring and their mother may share the same environment, and consequently similar microbial threats, we expect the immune molecules present in the progeny to be specific to the microbes that immune challenged the mother. We provide evidence in the mealworm beetle Tenebrio molitor that the antimicrobial activity found in the eggs is only active against Gram-positive bacteria, even when females were exposed to Gram-negative bacteria or fungi. Fungi were weak inducers of TGIP while we obtained similar levels of anti-Gram-positive activity using different bacteria for the maternal challenge. Furthermore, we have identified an antibacterial peptide from the defensin family, the tenecin 1, which spectrum of activity is exclusively directed toward Gram-positive bacteria as potential contributor to this antimicrobial activity. We conclude that maternal transfer of antimicrobial activity in the eggs of T. molitor might have evolved from persistent Gram-positive bacterial pathogens between insect generations
Fichier principal
Vignette du fichier
journal.ppat.1005178.PDF (1.42 Mo) Télécharger le fichier
Origine : Fichiers éditeurs autorisés sur une archive ouverte

Dates et versions

hal-01588049 , version 1 (15-09-2017)

Identifiants

Citer

Aurore Dubuffet, Caroline Zanchi, Gwendoline Boutet, Jérôme Moreau, Maria Teixeira, et al.. Trans-generational Immune Priming Protects the Eggs Only against Gram-Positive Bacteria in the Mealworm Beetle. PLoS Pathogens, 2015, 11 (10), pp.e1005178. ⟨10.1371/journal.ppat.1005178⟩. ⟨hal-01588049⟩
221 Consultations
223 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More