CLIFinder: Identification of LINE-1 Chimeric Transcripts in RNA-seq data

Abstract : L1 Chimeric Transcripts (LCTs) are initiated by repeated LINE-1 element antisense promoters and include the L1 5'UTR sequence in antisense orientation followed by the adjacent genomic region. LCTs have been characterized mainly using bioinformatics approaches to query dbEST. To take advantage of NGS data to unravel the transcriptome composition, we developed Chimeric LIne Finder (CLIFinder), a new bioinformatics tool. Using oriented paired-end RNA-seq data, we demonstrated that CLIFinder can identify genome-wide transcribed chimera sequences corresponding to potential LCTs. Moreover, CLIFinder can be adapted to study transcription from other repeat types.
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https://hal-clermont-univ.archives-ouvertes.fr/hal-01629422
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Marie-Elisa Pinson, Romain Pogorelcnik, Franck Court, Philippe Arnaud, Catherine Vaurs-Barrière. CLIFinder: Identification of LINE-1 Chimeric Transcripts in RNA-seq data. Bioinformatics, Oxford University Press (OUP), 2017, 〈10.1093/bioinformatics/btx671〉. 〈hal-01629422〉

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