MCR-1 and OXA-48 In Vivo Acquisition in KPC-Producing Escherichia coli after Colistin Treatment

Abstract : The spread of mcr-1-encoding plasmids into carbapenem-resistant En-terobacteriaceae raises concerns about the emergence of untreatable bacteria. We report the acquisition of mcr-1 in a carbapenem-resistant Escherichia coli strain after a 3-week course of colistin in a patient repatriated to France from Portugal. Whole-genome sequencing revealed that the Klebsiella pneumoniae carbapenemase-producing E. coli strain acquired two plasmids, an IncL OXA-48-encoding plasmid and an IncX4 mcr-1-encoding plasmid. This is the first report of mcr-1 in carbapenemase-encoding bacteria in France.
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Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2017, 61 (8), pp.e02540-16. 〈10.1128/AAC.02540-16〉
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https://hal-clermont-univ.archives-ouvertes.fr/hal-01639753
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Soumis le : jeudi 15 novembre 2018 - 16:59:03
Dernière modification le : vendredi 16 novembre 2018 - 11:10:03

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Racha Beyrouthy, Frédéric Robin, Aude Lessene, Igor Lacombat, Laurent Dortet, et al.. MCR-1 and OXA-48 In Vivo Acquisition in KPC-Producing Escherichia coli after Colistin Treatment. Antimicrobial Agents and Chemotherapy, American Society for Microbiology, 2017, 61 (8), pp.e02540-16. 〈10.1128/AAC.02540-16〉. 〈hal-01639753〉

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