Long-term improvement of breast cancer survivors’ quality of life by a 2-week group physical and educational intervention: 5-year update of the ‘PACThe’ trial

Abstract : Background: The advantages of adapted physical activity and nutritional education (APANE) on breast cancer prognosis and quality of life (QoL) are well known, but long-term results are lacking. Methods: A randomised controlled trial testing a 2-week intervention in hydrothermal centres including APANE enrolled 251 patients ost-chemotherapy. QoL and weight control were significantly improved at 12 months. A 5-year follow-up was performed to evaluate the persistence of improvements. Results: QoL increase (SF36) was persistent: effect-size at 2, 3, 4 and 5 years equalled respectively 0.27 (-0.01; 0.56), 0.28 (-0.02; 0.58), 0.41 (0.02; 0.81) and 0.45 (0.11; 0.80).Weight control observed after intervention lasted 2 years: 2.7% decrease at 1 year (P=0.0085), 2.5% at 2 years (P=0.025); and respectively for waist -2.4% (-3.6; -1.1) (P=0.000014) and -1.3% (-2.5; -0.1) (P=0.0072). Conclusions: A 2-week intervention in hydrothermal centres performed shortly after chemotherapy can durably improve breast cancer patients’ QoL and reduce weight.
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Submitted on : Thursday, January 4, 2018 - 12:33:39 PM
Last modification on : Wednesday, March 28, 2018 - 1:28:02 PM

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Fabrice Kwiatkowski, Marie-Ange Mouret-Reynier, Martine Duclos, François Bridon, Thierry Hanh, et al.. Long-term improvement of breast cancer survivors’ quality of life by a 2-week group physical and educational intervention: 5-year update of the ‘PACThe’ trial. British Journal of Cancer, Cancer Research UK, 2017, 116 (11), pp.1389 - 1393. ⟨10.1038/bjc.2017.112⟩. ⟨hal-01675319⟩

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