Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses

Maria Theresa Garcia-Conesa (1) , Karen Chambers (2) , Emilie Combet (3, 4) , Paula Pinto (5, 6, 7) , Mar Garcia-Aloy (8, 9, 10, 11) , Christina Andres-Lacueva (8, 9, 10, 11) , Sonia de Pascual-Teresa (12) , Pedro Mena (13) , Aleksandra Konic Ristic (14, 15, 16, 17) , Wendy J. Hollands (2) , Paul A. Kroon (2) , A. Rodriguez-Mateos (18) , Geoffrey Istas (18) , Christos A Kontogiorgis (19) , Dilip. K. Rai (20) , Eileen R. Gibney (21) , Christine Morand (22) , Juan Carlos Espin (1) , Antonio Gonzalez-Sarrias (1)

1 Centro de Edafologia y Biologia Aplicada del Segura
2 QIB - Quadram Institute Bioscience [Norwich, U.K.]
3 College of Medical Veterinary & Life Sciences
4 University of Glasgow
5 Department of Food Technology, Biotechnology and Nutrition
6 Insituto Politécnico de Santarém
7 Molecular Nutrition and Health Laboratory
8 Biomarkers and Nutritional & Food Metabolomics
9 UB - Universitat de Barcelona
10 Centro de Investigación Biomédica en Red Fragilidad y Envejecimiento Saludable
11 ISC - Instituto de Salud Carlos III [Madrid]
12 Department of Nutrition and Metabolism
13 Department of Food Science and Human Nutrition
14 Institute for Medical Research
15 University of Belgrade [Belgrade]
16 School of Food Science and Nutrition
17 University of Leeds
18 Department of Nutrition & Dietetics
19 Laboratory of Hygiene and Environmental Protection
20 Teagasac Food Research Centre
21 UCD Institute of Food and Health
22 UNH - Unité de Nutrition Humaine

Understanding interindividual variability in response to dietary polyphenols remains essential to elucidate their effects on cardiometabolic disease development. A meta-analysis of 128 randomized clinical trials was conducted to investigate the effects of berries and red grapes/wine as sources of anthocyanins and of nuts and pomegranate as sources of ellagitannins on a range of cardiometabolic risk biomarkers. The potential influence of various demographic and lifestyle factors on the variability in the response to these products were explored. Both anthocyanin-and ellagitannin-containing products reduced total-cholesterol with nuts and berries yielding more significant effects than pomegranate and grapes. Blood pressure was significantly reduced by the two main sources of anthocyanins, berries and red grapes/wine, whereas waist circumference, LDL-cholesterol, triglycerides, and glucose weremost significantly lowered by the ellagitannin-products, particularly nuts. Additionally, we found an indication of a small increase in HDL-cholesterol most significant with nuts and, in flow-mediated dilation by nuts and berries. Most of these effects were detected in obese/overweight people but we found limited or non-evidence in normoweight individuals or of the influence of sex or smoking status. The effects of other factors, i.e., habitual diet, health status or country where the study was conducted, were inconsistent and require further investigation.

Mots clés: ellagitannins; anthocyanins; interindividual variability; meta-analysis; cardiometabolic disorders; pomegranate; nuts; berries; red wine; red grapes; cardiovascular disease; metaanalysis

Mots clés: polyphénol alimentaire; maladie cardiovasculaire; méta analyse

Domaines: Alimentation et Nutrition; Chimie analytique

Maria Theresa Garcia-Conesa, Karen Chambers, Emilie Combet, Paula Pinto, Mar Garcia-Aloy, et al.. Meta-Analysis of the Effects of Foods and Derived Products Containing Ellagitannins and Anthocyanins on Cardiometabolic Biomarkers: Analysis of Factors Influencing Variability of the Individual Responses. International Journal of Molecular Sciences, 2018, 19 (3), ⟨10.3390/ijms19030694⟩. ⟨hal-01831438⟩