D. N. Louis, H. Ohgaki, O. D. Wiestler, and W. K. Cavenee, World Health Organization Histological Classification of Tumours of the Central Nervous System. (France: International Agency for Research on Cancer, 2016.

M. Preusser, S. De-ribaupierre, A. Wohrer, S. C. Erridge, M. Hegi et al., Current concepts and management of glioblastoma, Ann Neurol, vol.70, pp.9-21, 2011.

R. Y. Bai, V. Staedtke, and G. J. Riggins, Molecular targeting of glioblastoma: Drug discovery and therapies, Trends Mol Med, vol.17, issue.11, pp.301-313, 2011.

N. A. Charles, E. C. Holland, R. Gilbertson, R. Glass, and H. Kettenmann, The brain tumor microenvironment, Glia, vol.59, pp.1169-80, 2011.

M. Hadziahmetovic, K. Shirai, and A. Chakravarti, Recent advancements in multimodality treatment of gliomas, Future Oncol, vol.7, pp.1169-83, 2011.

F. E. Bleeker, R. J. Molenaar, and S. Leenstra, Recent advances in the molecular understanding of glioblastoma, J Neurooncol, vol.108, pp.11-27, 2012.

C. P. Ponting, P. L. Oliver, and W. Reik, Evolution and functions of long noncoding RNAs, Cell, vol.136, pp.629-670, 2009.

E. A. Gibb, C. J. Brown, and W. L. Lam, The functional role of long non-coding RNA in human carcinomas, Molecular cancer, vol.10, 2011.

T. R. Mercer, M. E. Dinger, and J. S. Mattick, Long non-coding RNAs: insights into functions, Nat Rev Genet, vol.10, pp.155-164, 2009.

J. L. Rinn, M. Kertesz, J. K. Wang, S. L. Squazzo, X. Xu et al., Functional demarcation of active and silent chromatin domains in human HOX loci by noncoding RNAs, Cell, vol.129, pp.1311-1334, 2007.

M. Huarte and J. L. Rinn, Large non-coding RNAs: missing links in cancer?, Hum Mol Genet, vol.19, pp.152-61, 2010.

M. C. Tsai, O. Manor, Y. Wan, N. Mosammaparast, J. K. Wang et al., Long noncoding RNA as modular scaffold of histone modification complexes, Science, vol.329, pp.689-93, 2010.

A. Bhan and S. S. Mandal, LncRNA HOTAIR: A master regulator of chromatin dynamics and cancer, Biochim Biophys Acta, vol.1856, pp.151-64, 2015.

M. Hajjari and A. Salavaty, HOTAIR: an oncogenic long noncoding RNA in different cancers, Cancer Biol Med, vol.12, pp.1-9, 2015.

X. Yu and Z. Li, Long non-coding RNA HOTAIR: A novel oncogene (Review), Mol Med Rep, vol.12, pp.5611-5619, 2015.

J. X. Zhang, L. Han, Z. S. Bao, Y. Y. Wang, L. Y. Chen et al., Chinese Glioma Cooperative Group. HOTAIR, a cell cycleassociated long noncoding RNA and a strong predictor of survival, is preferentially expressed in classical and mesenchymal glioma, Neuro Oncol, vol.15, pp.1595-603, 2013.

J. Ke, Y. L. Yao, J. Zheng, P. Wang, Y. H. Liu et al., Knockdown of long non-coding RNA HOTAIR inhibits malignant biological behaviors of human glioma cells via modulation of miR-326, Oncotarget, vol.6, pp.21934-21983, 2015.

G. Wang, Z. Li, N. Tian, L. Han, Y. Fu et al., miR-148b-3p inhibits malignant biological behaviors of human glioma cells induced by high HOTAIR expression, Oncol Lett, vol.12, pp.879-86, 2016.

K. Zhang, X. Sun, X. Zhou, L. Han, L. Chen et al., Long non-coding RNA HOTAIR promotes glioblastoma cell cycle progression in an EZH2 dependent manner, Oncotarget, vol.6, pp.537-583, 2015.

K. Huang, J. Sun, C. Yang, Y. Wang, B. Zhou et al., HOTAIR upregulates an 18-gene cell cycle-related mRNA network in glioma, Int J Oncol, 2017.

A. Murat, E. Migliavacca, T. Gorlia, W. L. Lambiv, T. Shay et al., Stem cell-related "self-renewal" signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma, Journal of clinical oncology, vol.26, pp.3015-3039, 2008.

W. A. Freije, F. E. Castro-vargas, Z. Fang, S. Horvath, T. Cloughesy et al., Gene expression profiling of gliomas strongly predicts survival, Cancer research, vol.64, pp.6503-6513, 2004.

L. Sun, A. M. Hui, Q. Su, A. Vortmeyer, Y. Kotliarov et al., Neuronal and glioma-derived stem cell factor induces angiogenesis within the brain, Cancer Cell, vol.9, pp.287-300, 2006.

H. S. Phillips, S. Kharbanda, R. Chen, W. F. Forrest, R. H. Soriano et al., Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis, Cancer Cell, vol.9, pp.157-73, 2006.

Q. Wang, B. Hu, X. Hu, H. Kim, M. Squatrito et al., Tumor Evolution of Glioma-Intrinsic Gene Expression Subtypes Associates with Immunological Changes in the Microenvironment, Cancer Cell, vol.32, pp.42-56, 2017.

M. Pojo, C. S. Goncalves, A. Xavier-magalhaes, A. I. Oliveira, T. Goncalves et al., A transcriptomic signature mediated by HOXA9 promotes human glioblastoma initiation, aggressiveness and resistance to temozolomide, Oncotarget, vol.6, pp.7657-74, 2015.

C. S. Goncalves, A. Xavier-magalhaes, M. Pojo, A. I. Oliveira, S. Correia et al., Transcriptional profiling of HOXA9-regulated genes in human glioblastoma cell models, Genom Data, vol.5, pp.54-62, 2015.

B. M. Costa, J. S. Smith, Y. Chen, J. Chen, H. S. Phillips et al., Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma, Cancer research, vol.70, pp.453-62, 2010.

N. Gaspar, L. Marshall, L. Perryman, D. A. Bax, S. E. Little et al., MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature, Cancer research, vol.29, pp.9243-52, 2010.
DOI : 10.1158/0008-5472.can-10-1250
URL : http://cancerres.aacrjournals.org/content/70/22/9243.full.pdf

R. A. Gupta, N. Shah, K. C. Wang, J. Kim, H. M. Horlings et al., Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis, Nature, vol.464, pp.1071-1077, 2010.
DOI : 10.1038/nature08975
URL : http://europepmc.org/articles/pmc3049919?pdf=render

X. Zhou, Y. Ren, J. Zhang, C. Zhang, K. Zhang et al., HOTAIR is a therapeutic target in glioblastoma, Oncotarget, vol.6, pp.8353-65, 2015.
DOI : 10.18632/oncotarget.3229
URL : http://www.oncotarget.com/index.php?journal=oncotarget&page=article&op=download&path%5B%5D=3229&path%5B%5D=8286

E. B. Bian, C. C. Ma, X. J. He, C. Wang, G. Zong et al., Epigenetic modification of miR-141 regulates SKA2 by an endogenous 'sponge' HOTAIR in glioma

, Oncotarget, vol.7, pp.30610-30635, 2016.

A. K. Maunakea, R. P. Nagarajan, M. Bilenky, T. J. Ballinger, D. Souza et al., Conserved role of intragenic DNA methylation in regulating alternative promoters, Nature, vol.466, pp.253-260, 2010.

M. C. Lorincz, D. R. Dickerson, M. Schmitt, and M. Groudine, Intragenic DNA methylation alters chromatin structure and elongation efficiency in mammalian cells, Nature structural & molecular biology, vol.11, pp.1068-75, 2004.

L. Wang, X. Zeng, S. Chen, L. Ding, J. Zhong et al., BRCA1 is a negative modulator of the PRC2 complex, The EMBO journal, vol.32, pp.1584-97, 2013.

, Comprehensive genomic characterization defines human glioblastoma genes and core pathways, Nature, vol.455, pp.1061-1069, 2008.

A. M. Khalil, M. Guttman, M. Huarte, M. Garber, A. Raj et al., Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression, Proc Natl Acad Sci USA, vol.106, pp.11667-72, 2009.

B. M. Costa, J. S. Smith, Y. Chen, J. Chen, H. S. Phillips et al., Reversing HOXA9 oncogene activation by PI3K inhibition: epigenetic mechanism and prognostic significance in human glioblastoma, Cancer Res, vol.70, pp.453-62, 2010.

A. Murat, E. Migliavacca, T. Gorlia, W. L. Lambiv, T. Shay et al., Stem cell-related "self-renewal" signature and high epidermal growth factor receptor expression associated with resistance to concomitant chemoradiotherapy in glioblastoma, J Clin Oncol, vol.26, pp.3015-3039, 2008.

N. Gaspar, L. Marshall, L. Perryman, D. A. Bax, S. E. Little et al., MGMT-independent temozolomide resistance in pediatric glioblastoma cells associated with a PI3-kinase-mediated HOX/stem cell gene signature, Cancer Res, vol.70, pp.9243-52, 2010.

P. M. Gilbert, J. K. Mouw, M. A. Unger, J. N. Lakins, M. K. Gbegnon et al., HOXA9 regulates BRCA1 expression to modulate human breast tumor phenotype, J Clin Invest, vol.120, pp.1535-50, 2010.

A. Xavier-magalhaes, A. I. Oliveira, J. V. De-castro, M. Pojo, C. S. Goncalves et al., Effects of the functional HOTAIR rs920778 and rs12826786 genetic variants in glioma susceptibility and patient prognosis, J Neurooncol, vol.132, pp.27-34, 2017.

T. R. Mercer, M. E. Dinger, S. M. Sunkin, M. F. Mehler, and J. S. Mattick, Specific expression of long noncoding RNAs in the mouse brain, Proc Natl Acad Sci U S A, vol.105, pp.716-737, 2008.

C. Pastori, P. Kapranov, C. Penas, V. Peschansky, C. H. Volmar et al., The Bromodomain protein BRD4 controls HOTAIR, a long noncoding RNA essential for glioblastoma proliferation, Proc Natl Acad Sci U S A, vol.112, pp.8326-8357, 2015.

Y. Jiang, Q. Zhang, J. Bao, C. Du, J. Wang et al., Schisandrin B inhibits the proliferation and invasion of glioma cells by regulating the HOTAIR-micoRNA-125amTOR pathway, Neuroreport, vol.28, pp.93-100, 2017.

J. Chen, C. Lin, W. Yong, Y. Ye, and Z. Huang, Calycosin and genistein induce apoptosis by inactivation of HOTAIR/pAkt signaling pathway in human breast cancer MCF-7 cells, Cell Physiol Biochem, vol.35, pp.722-730, 2015.

T. Chiyomaru, S. Yamamura, S. Fukuhara, H. Yoshino, T. Kinoshita et al., Genistein inhibits prostate cancer cell growth by targeting miR-34a and oncogenic HOTAIR, PloS One, vol.8, p.70372, 2013.

M. Hayakawa, H. Kaizawa, H. Moritomo, T. Koizumi, T. Ohishi et al., Synthesis and biological evaluation of pyrido, Bioorganic & medicinal chemistry letters, vol.17, pp.2438-2480, 2007.

C. J. Vlahos, W. F. Matter, K. Y. Hui, and R. F. Brown, A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002), The Journal of biological chemistry, vol.269, pp.5241-5249, 1994.

J. Tan, X. Yang, L. Zhuang, X. Jiang, W. Chen et al., Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in cancer cells, Genes & development, vol.21, pp.1050-63, 2007.

Y. Liang, D. Quenelle, J. L. Vogel, C. Mascaro, A. Ortega et al., A novel selective LSD1/KDM1A inhibitor epigenetically blocks herpes simplex virus lytic replication and reactivation from latency, mBio, vol.4, pp.558-570, 2013.

T. Schenk, W. C. Chen, S. Gollner, L. Howell, J. L. Hebestreit et al., Inhibition of the LSD1 (KDM1A) demethylase reactivates the all-trans-retinoic acid differentiation pathway in acute myeloid leukemia, Nature medicine, vol.18, pp.605-616, 2012.

G. M. Elsayed, H. R. Nassar, A. Zaher, E. H. Elnoshokaty, and M. M. Moneer, Prognostic value of IDH1 mutations identified with PCR-RFLP assay in acute myeloid leukemia patients, J Egypt Natl Canc Inst, vol.26, pp.43-52, 2014.

F. Ducray, E. Criniere, A. Idbaih, K. Mokhtari, Y. Marie et al., alphaInternexin expression identifies 1p19q codeleted gliomas, Neurology, vol.72, pp.156-61, 2009.

F. Ducray, K. Mokhtari, E. Criniere, A. Idbaih, Y. Marie et al., Diagnostic and prognostic value of alpha internexin expression in a series of 409 gliomas, Eur J Cancer, vol.47, pp.802-810, 2011.

D. A. Bax, S. E. Little, N. Gaspar, L. Perryman, L. Marshall et al., Molecular and phenotypic characterisation of paediatric glioma cell lines as models for preclinical drug development, PloS One, vol.4, 2009.

, Comprehensive genomic characterization defines human glioblastoma genes and core pathways, Nature, vol.455, pp.1061-1069, 2008.

D. R. Rhodes, S. Kalyana-sundaram, V. Mahavisno, R. Varambally, J. Yu et al., Oncomine 3.0: genes, pathways, and networks in a collection of 18,000 cancer gene expression profiles, Neoplasia, vol.9, pp.166-80, 2007.

K. Cartharius, K. Frech, K. Grote, B. Klocke, M. Haltmeier et al., MatInspector and beyond: promoter analysis based on transcription factor binding sites, Bioinformatics, vol.21, pp.2933-2975, 2005.

K. Quandt, K. Frech, H. Karas, E. Wingender, and T. Werner, MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data, Nucleic Acids Res, vol.23, pp.4878-84, 1995.

J. D. Nelson, O. Denisenko, and K. Bomsztyk, Protocol for the fast chromatin immunoprecipitation (ChIP) method, Nat Protoc, vol.1, pp.179-85, 2006.

K. J. Livak and T. D. Schmittgen, Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method, Methods, vol.25, pp.402-410, 2001.

X. Liu, Classification accuracy and cut point selection, Stat Med, vol.31, pp.2676-86, 2012.

W. J. Youden, Index for rating diagnostic tests, Cancer, vol.3, pp.2-3, 1950.

K. Hajian-tilaki, Receiver Operating Characteristic (ROC) Curve Analysis for Medical Diagnostic Test Evaluation, Caspian J Intern Med, vol.4, pp.627-662, 2013.