Reference ranges for serum S100B neuroprotein specific to infants under four months of age

Jeanne Simon-Pimmel , Fleur Lorton , Damien Masson (1) , Damien Bouvier (2, 3) , Matthieu Hanf (4) , Christele Gras-Le Guen (5)

1 LIGM - Laboratoire d'Informatique Gaspard-Monge
2 GReD - Génétique, Reproduction et Développement
3 UCA [2017-2020] - Université Clermont Auvergne [2017-2020]
4 CIC - Antilles Guyane - Centre d'Investigation Clinique Antilles-Guyane
5 Clinique Médicale et Service d'Urgences Pédiatriques, Hôpital Mère-Enfant

Minor head traumatisms are a common reason for consultation in paediatric emergency departments. The diagnosis of traumatic brain injuries involves performing a cranial computed tomography (CCT), associated with a risk of cancer due to the radiation. The serum S100B is an effective biomarker used to reduce reliance on CCT. While reference ranges have been determined, the limited number of cases regarding infants less than 4months of age has not allowed this biomarker to be used with this age group. Our study aimed to determine reference ranges for serum S100B based on a larger number of infants from birth to 4months of age.

Mots clés: Children; Head trauma; Infants; Reference ranges; S100B protein

Domaines: Biochimie [q-bio.BM]

Jeanne Simon-Pimmel, Fleur Lorton, Damien Masson, Damien Bouvier, Matthieu Hanf, et al.. Reference ranges for serum S100B neuroprotein specific to infants under four months of age. Clinical Biochemistry, 2017, 50 (18), pp.1056 - 1060. ⟨10.1016/j.clinbiochem.2017.08.014⟩. ⟨hal-01919740⟩