Prevalence of aortic valve dystrophy and insufficiency in a cohort of 255 HIV-positive patients followed-up in a cardiology department between 2012 and 2014

Abstract : Objectives: To study valve appearance and the presence of valve disease in a cohort of people living with HIV (PLHIV). Design: A prospective study of PLHIV examined at the cardiology department of the Clermont Ferrand university hospital group (CHU) between January 1, 2012, and December 31, 2014. Were excluded those with a history of infection associated with a possible endocarditis. Methods: Demographic, medical characteristics and cardiovascular disease risk factors at time of cardiovascular examination and Doppler-echocardiography were recorded and analyzed. Results: In total, 903 PLHIV were examined in the infectious diseases department, 255 of whom were included. These consisted of 67 women (26.3%) and 188 men, of a mean age of 51.2 ±9.7 years, in whom coronary artery disease was diagnosed in 18 patients (7.0%), two women and 16 men, representing a prevalence of 3.0% in females and 8.5% in males. The appearance of the aortic cusps was considered dystrophic in 14.1% of cases (36/ 255), dysplastic in two cases (0.8%), exhibiting a bicuspid deformity in one case. The prevalence of aortic valve abnormality was therefore 6.0% in the women (4/67) and 17.0% in the men (32/188). On facing off this data with the Kora Monica study findings, an increase in prevalence appears only to truly manifest after 50 years of age.We registered 35 aortic insufficiency cases (13.7%), representing a higher incidence than that of the Framingham cohort, with age and masculine gender being the determining factors. Conclusion: Valve disease, along with coronary artery disease, should be closely monitored in PLHIV.
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Contributor : Fabrice Kwiatkowski <>
Submitted on : Thursday, January 4, 2018 - 12:19:14 PM
Last modification on : Sunday, March 31, 2019 - 1:15:56 AM

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C. Jacomet, G. Illes, F. Kwiatkowski, M. Vidal, N. Mrozek, et al.. Prevalence of aortic valve dystrophy and insufficiency in a cohort of 255 HIV-positive patients followed-up in a cardiology department between 2012 and 2014. International Journal of Cardiology, Elsevier, 2016, 220, pp.82 - 86. ⟨10.1016/j.ijcard.2016.06.237⟩. ⟨hal-01675311⟩

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