Synthesis of all-trans-beta-carotene retinoids and derivatives labelled with 14C

El-Mostafa Azim (1) , Philippe Auzeloux (2, 1) , Jean-Claude Maurizis (1) , Véronique Braesco (3) , Pascal Grolier , Annie Veyre (1) , Jean-Claude Madelmont (2, 1)

1 Etude Métabolique des Molécules Marquées
2 IMTV - Imagerie Moléculaire et Thérapie Vectorisée
3 Danone Research

In this paper we report the synthesis of all-trans Retinoic acid, Retinal, Retinol specifically labelled with 14C at position 7 and all-trans Beta-carotene labelled at positions 7 and 7′, with more than 98% radiochemical purity. All products were obtained with about 15% overall yield from 14C sodium cyanide.

Domaines: Chimie

El-Mostafa Azim, Philippe Auzeloux, Jean-Claude Maurizis, Véronique Braesco, Pascal Grolier, et al.. Synthesis of all-trans-beta-carotene retinoids and derivatives labelled with 14C. Journal of Labelled Compounds and Radiopharmaceuticals, 1996, 38 (5), pp.441 - 451. ⟨10.1002/(SICI)1099-1344(199605)38:5<441::AID-JLCR848>3.0.CO;2-O⟩. ⟨hal-01494470⟩